ACTIVIN A TARGETS EXTRASYNAPTIC NMDA RECEPTORS TO AMELIORATE NEURONAL AND BEHAVIORAL DEFICITS IN A MOUSE MODEL OF HUNTINGTON DISEASE

Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Dining Seating Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Therefore,

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Outcomes of extracorporeal membrane oxygenation in adult patients with hypoxemic respiratory failure refractory to mechanical ventilation

Introduction: Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal life support that has been used to support cardiopulmonary disease refractory to conventional therapy.The experience with the use of ECMO in acute hypoxemic respiratory failure is still limited.The aim of this study was to report clinical outcomes in adult patients

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A Neonicotinoid Insecticide at a Rate Found in Nectar Reduces Longevity but Not Oogenesis in Monarch Butterflies, Danaus plexippus (L.). (Lepidoptera: Nymphalidae)

The monarch butterfly in North America has suffered a serious population decline since the mid-1990s.The introduction and widespread use of neonicotinoid insecticides during the same time period has been suggested as a potential driver of this decline but no studies have looked at the impact of these insecticides on adult monarchs.A brief laborator

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